Size Does Matter. Sterically Demanding Metallocene-Substituted 3-Methylidene-Oxindoles Exhibit Poor Kinase Inhibitory Action
Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher J., Tizzard, Graham J., Coles, Simon J., Bingham, John P., Hartley, John A., Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size Does Matter. Sterically Demanding Metallocene-Substituted 3-Methylidene-Oxindoles Exhibit Poor Kinase Inhibitory Action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333
Full text not available from this repository. (Request a copy)Abstract
1,3-Dihydro-2H-indol-2-one (1) undergoes microwave-mediated Knoevenagel condensations with 1,2,3,4,5-pentaphenylferrocene carboxaldehyde (2b) or (eta(4)-tetraphenyl-cyclobutadiene)(eta(5)-cyclopentadienylcarboxaldehyd e)cobalt (2c) to afford metallocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-one 4 or 5, respectively, in excellent yields as separable E,Z-sfereoisomeric mixtures. Both 4 and 5 exhibited poor kinase inhibition and no appreciable cytotoxicity toward a leukemia cell line, attributed to the steric bulk of the metallocene substituents.
Item Type: | Article |
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Additional Information: | Spencer, John Amin, Jahangir Coxhead, Peter McGeehan, John Richards, Christopher J. Tizzard, Graham J. Coles, Simon J. Bingham, John P. Hartley, John A. Feng, Li Meggers, Eric Guille, Matthew |
Faculty \ School: | Faculty of Science > School of Chemistry |
Depositing User: | Rachel Smith |
Date Deposited: | 21 Feb 2012 11:27 |
Last Modified: | 25 May 2022 13:31 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/37270 |
DOI: | 10.1021/om200278j |
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