Sharma, Sunil V., Jothivasan, Vishnu K., Newton, Gerald L., Upton, Heather, Wakabayashi, Judy I., Kane, Melissa G., Roberts, Alexandra A., Rawat, Mamta, La Clair, James J. and Hamilton, Chris J. (2011) Chemical and chemoenzymatic syntheses of bacillithiol, a unique low molecular weight thiol amongst low G + C Gram positive bacteria. Angewandte Chemie-International Edition, 50 (31). pp. 7101-7104. ISSN 1433-7851
Full text not available from this repository. (Request a copy)Abstract
The full monty: The recently discovered thiol cofactor bacillithiol (BSH), its biosynthetic precursors, and its symmetrical disulfide are prepared in two ways. The fosfomycin resistance protein (FosB) is shown to be a BSH-utilizing enzyme. It displays bacillithiol-S-transferase activity with a strong preference for BSH over L-cysteine as its thiol substrate.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Pharmacy |
UEA Research Groups: | Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
Depositing User: | Users 2731 not found. |
Date Deposited: | 01 Feb 2012 13:17 |
Last Modified: | 30 Mar 2024 22:30 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/36711 |
DOI: | 10.1002/anie.201100196 |
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