Amorphous drug-PVP dispersions: Application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state

Tobyn, Michael, Brown, Jonathan, Dennis, Andrew B., Fakes, Michael, Gao, Qi, Gamble, John, Khimyak, Yaroslav Z., McGeorge, Gary, Patel, Chhaya, Sinclair, Wayne, Timmins, Peter and Yin, Shawn (2009) Amorphous drug-PVP dispersions: Application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state. Journal of Pharmaceutical Sciences, 98 (9). pp. 3456-3468. ISSN 1520-6017

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Abstract

We report the case of BMS-488043-PVP solid dispersions which when analysed using modulated DSC showed compliance with the Gordon–Taylor model, confirming ideal mixing behaviour of the two components. The nature or presence of stabilising interactions between drug and PVP could not be confirmed using this technique. Use of FT-IR, Raman and solid-state NMR spectroscopy confirmed the presence of stabilising hydrogen bond interactions between the drug and PVP. Similar interactions are present as intermolecular bonds in the crystalline and pure amorphous drug system. The Gordon–Taylor equation, as it is not predictive of the presence of intermolecular bonds such as hydrogen bonding in an amorphous dispersion, may underestimate the likely physical stability of solid dispersions which are produced and stabilised by these interactions. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3456–3468, 2009

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rhiannon Harvey
Date Deposited: 31 Jan 2012 11:16
Last Modified: 21 Apr 2020 17:27
URI: https://ueaeprints.uea.ac.uk/id/eprint/36610
DOI: 10.1002/jps.21738

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