Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru

Cohen, Ted, Murray, Megan B., Abubakar, Ibrahim, Zhang, Zibiao, Sloutsky, Alexander, Arteaga, Fernando, Chalco, Katiuska, Franke, Molly F. and Becerra, Mercedes C. (2011) Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru. Emerging Infectious Diseases, 17 (6). pp. 969-975.

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Abstract

Two cases of multidrug-resistant tuberculosis (MDR TB) in a household are assumed to reflect within-household transmission. However, in high-incidence areas of MDR TB, secondary cases may arise through exposure to MDR TB in the community. To estimate the frequency of multiple introductions of MDR TB into households, we used spoligotyping and 24-loci mycobacterial interspersed repetitive unit- variable number tandem repeats to classify isolates from 101 households in Lima, Peru, in which >1 MDR TB patient received treatment during 1996-2004. We found different MDR TB strains in >10% of households. Alternate approaches for classifying matching strains produced estimates of multiple introductions in

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 11 Jan 2012 15:46
Last Modified: 21 Apr 2020 16:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/36121
DOI: 10.3201/eid1706.101471

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