A geographically-restricted but prevalent Mycobacterium tuberculosis strain identified in the West Midlands region of the UK between 1995 and 2008

Evans, Jason T., Serafino Wani, Robert L., Anderson, Laura, Gibson, Andrea L., Smith, E. Grace, Wood, Annette, Olowokure, Babatunde, Abubakar, I, Mann, Jonathan S., Gardiner, Sarah, Jones, Helen, Sonnenberg, Pam and Hawkey, Peter M. (2011) A geographically-restricted but prevalent Mycobacterium tuberculosis strain identified in the West Midlands region of the UK between 1995 and 2008. PLoS One, 6 (3). ISSN 1932-6203

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Abstract

Background: We describe the identification of, and risk factors for, the single most prevalent Mycobacterium tuberculosis strain in the West Midlands region of the UK. Methodology/Principal Findings: Prospective 15-locus MIRU-VNTR genotyping of all M. tuberculosis isolates in the West Midlands between 2004 and 2008 was undertaken. Two retrospective epidemiological investigations were also undertaken using univariable and multivariable logistic regression analysis. The first study of all TB patients in the West Midlands between 2004 and 2008 identified a single prevalent strain in each of the study years (total 155/3,056 (5%) isolates). This prevalent MIRU-VNTR profile (32333 2432515314 434443183) remained clustered after typing with an additional 9-loci MIRU-VNTR and spoligotyping. The majority of these patients (122/155, 79%) resided in three major cities located within a 40 km radius. From the apparent geographical restriction, we have named this the “Mercian” strain. A multivariate analysis of all TB patients in the West Midlands identified that infection with a Mercian strain was significantly associated with being UK-born (OR = 9.03, 95%CI = 4.56–17.87, p

Item Type: Article
Additional Information: © 2011 Evans et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 11 Jan 2012 15:33
Last Modified: 21 Apr 2020 16:42
URI: https://ueaeprints.uea.ac.uk/id/eprint/36120
DOI: 10.1371/journal.pone.0017930

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