The role of the Interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident

Bradshaw, Louise, Davies, Elizabeth, Devine, Michael, Flanagan, Peter, Kelly, Paul, O'Connor, Kevin, Drobniewski, Francis, Nikolayevskyy, Vladislav and Abubakar, Ibrahim (2011) The role of the Interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident. PLoS One, 6 (6). ISSN 1932-6203

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Abstract

In 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker. Interferon gamma release assays (IGRAs) were used to test 333 patients and 98 staff. We investigated for evidence of onward transmission and recent infection based on analysis of clinical, demographic and IGRA data. We also described within-patient variability of IGRA results. Among patients and staff, increasing age of patients was the only factor associated with IGRA positivity. Greatest within-subject variability of IU/mL in serially-tested patients/staff was seen in those with a positive IGRA test and this did not correlate with increased exposure to the index case. IGRA positivity being largely explained by increasing age in patients and previous TB contact in staff lends weight to the conclusion that IGRA positivity reflected previous infection rather than recent transmission.

Item Type: Article
Additional Information: © 2011 Bradshaw et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 11 Jan 2012 14:25
Last Modified: 21 Apr 2020 16:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/36100
DOI: 10.1371/journal.pone.0020770

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