Demonstration of TGF-beta and XIII-alpha in Endocardial Biopsies of Carcinoid Heart Disease Patients: an Immunofluorescence Study

Diepholz, Dorgrit, Wilke, Andreas, Maisch, Bernhard and Steverding, Dietmar (2011) Demonstration of TGF-beta and XIII-alpha in Endocardial Biopsies of Carcinoid Heart Disease Patients: an Immunofluorescence Study. Cardiology Research, 2 (3). pp. 119-122. ISSN 1923-2837

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Abstract

Background: Serotonin and other vasoactive substances play a critical role in the development of carcinoid heart disease, but the exact etiology of the illness is still unknown. Methods: By using immunofluorescence microscopy, we investigated the expression of transforming growth factor-beta (TGF-beta) and the presence of fibrin-stabilizing factor (XIIIalpha) in endomyocardial biopsy specimens of patients with carcinoid heart disease. In addition, the tissue integrity of the specimens was studied by staining for laminin. Results: Both TGF-beta and XIIIalpha co-localized in the endocardium beneath carcinoid plaques: while TGF-beta was found within myocytes, XIIIalpha was detected on the surface of cells in fibrotic lesions stretching out into the tissue. Laminin staining revealed that the integrity of the endocardium was dissolved and that the tissue consisted of hypertrophic and hypotrophic myocytes. Conclusions: The results suggest that the presence of TGF-beta and XIIIalpha in carcinoid heart lesions indicates that endocardial damage induced by serotonin and other vasoactive substances gives rise to an overshooting wound healing process.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 12 Dec 2011 15:17
Last Modified: 21 Jul 2020 23:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/35699
DOI: 10.4021/cr48w

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