Cysteine peptidases of kinetoplastid parasites

Steverding, Dietmar, Caffrey, Conor R. and Lima, Ana-Paule (2011) Cysteine peptidases of kinetoplastid parasites. Advances in Experimental Medicine and Biology, 712. pp. 84-99. ISSN 0065-2598

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We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage‑specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host’s immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Rhiannon Harvey
Date Deposited: 12 Dec 2011 14:46
Last Modified: 21 Apr 2020 16:42
DOI: 10.1007/978-1-4419-8414-2_6

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