Cysteine peptidases of kinetoplastid parasites

Steverding, Dietmar, Caffrey, Conor R. and Lima, Ana-Paule (2011) Cysteine peptidases of kinetoplastid parasites. Advances in Experimental Medicine and Biology, 712. pp. 84-99. ISSN 0065-2598

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We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage‑specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host’s immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Rhiannon Harvey
Date Deposited: 12 Dec 2011 14:46
Last Modified: 21 Nov 2022 15:30
DOI: 10.1007/978-1-4419-8414-2_6

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