β -Lactamases- the Threat Renews

Livermore, DM (2009) β -Lactamases- the Threat Renews. Current Protein and Peptide Science, 10 (5). pp. 397-400. ISSN 1875-5550

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Abstract

ß-Lactamases are the greatest single source of resistance to ß-lactam antibiotics. For over 60 years, clinicians have seen a pattern whereby useful new ß-lactam analogues are introduced but then select for new ß-lactamases that cause resistance. Thus, penicillin G was undermined by swift accumulation of staphylococcal penicillinase, ampicillin by TEM- 1 enzyme and modern oxymino cephalosporins by “extended-spectrum” ß-lactamases. Tony Fink's work contributed greatly to our understanding of the mechanisms and active site function of ß-lactamases and this knowledge now informs the search for new ß-lactams and ß-lactamase inhibitors.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Users 2731 not found.
Date Deposited: 24 Oct 2011 11:08
Last Modified: 21 Apr 2020 17:26
URI: https://ueaeprints.uea.ac.uk/id/eprint/35143
DOI: 10.2174/138920309789351994

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