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Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703
(2009)
β -Lactamases- the Threat Renews.
Current Protein and Peptide Science, 10 (5).
pp. 397-400.
ISSN 1875-5550
Abstract
ß-Lactamases are the greatest single source of resistance to ß-lactam antibiotics. For over 60 years, clinicians have seen a pattern whereby useful new ß-lactam analogues are introduced but then select for new ß-lactamases that cause resistance. Thus, penicillin G was undermined by swift accumulation of staphylococcal penicillinase, ampicillin by TEM- 1 enzyme and modern oxymino cephalosporins by “extended-spectrum” ß-lactamases. Tony Fink's work contributed greatly to our understanding of the mechanisms and active site function of ß-lactamases and this knowledge now informs the search for new ß-lactams and ß-lactamase inhibitors.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 24 Oct 2011 11:08 |
| Last Modified: | 06 Jan 2023 16:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/35143 |
| DOI: | 10.2174/138920309789351994 |
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