Susceptibility of Klebsiella pneumoniae Isolates from Intra-Abdominal Infections and Molecular Characterization of Ertapenem-Resistant Isolates

Hawser, Stephen P., Bouchillon, Samuel K., Lascols, Christine, Hackel, Meredith, Hoban, Daryl J., Badal, Robert E., Woodford, Neil and Livermore, David M. ORCID: https://orcid.org/0000-0002-9856-3703 (2011) Susceptibility of Klebsiella pneumoniae Isolates from Intra-Abdominal Infections and Molecular Characterization of Ertapenem-Resistant Isolates. Antimicrobial Agents and Chemotherapy, 55 (8). pp. 3917-3921. ISSN 0066-4804

Full text not available from this repository. (Request a copy)

Abstract

A total of 2,841 clinical isolates of Klebsiella pneumoniae from intra-abdominal infections worldwide were collected in the Study for Monitoring Antimicrobial Resistance Trends (SMART) during 2008 and 2009. Overall, 22.4% of isolates had extended-spectrum β-lactamases (ESBLs). The most active antibiotics among the 11 tested were imipenem, amikacin, and ertapenem, though even these, like all other comparators, were less consistently active against ESBL-positive isolates than against ESBL-negative isolates. Globally, 6.5% of isolates were ertapenem resistant based on the June 2010 clinical breakpoints published by the Clinical and Laboratory Standards Institute, with MICs of ≥1 μg/ml. Molecular characterization of 43 isolates with ertapenem MICs of ≥4 μg/ml showed that they variously produced CTX-M or SHV ESBLs combined with altered impermeability and/or had KPC (n = 28), OXA-48 (n = 3), or VIM (n = 1) carbapenemases. Further monitoring of ertapenem susceptibility and molecular characterization of ertapenem-resistant isolates are needed.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Users 2731 not found.
Date Deposited: 24 Oct 2011 11:01
Last Modified: 25 Sep 2022 00:42
URI: https://ueaeprints.uea.ac.uk/id/eprint/35140
DOI: 10.1128/AAC.00070-11

Actions (login required)

View Item View Item