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Hawser, Stephen P., Bouchillon, Samuel K., Lascols, Christine, Hackel, Meredith, Hoban, Daryl J., Badal, Robert E., Woodford, Neil and Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703
(2011)
Susceptibility of Klebsiella pneumoniae Isolates from Intra-Abdominal Infections and Molecular Characterization of Ertapenem-Resistant Isolates.
Antimicrobial Agents and Chemotherapy, 55 (8).
pp. 3917-3921.
ISSN 0066-4804
Abstract
A total of 2,841 clinical isolates of Klebsiella pneumoniae from intra-abdominal infections worldwide were collected in the Study for Monitoring Antimicrobial Resistance Trends (SMART) during 2008 and 2009. Overall, 22.4% of isolates had extended-spectrum β-lactamases (ESBLs). The most active antibiotics among the 11 tested were imipenem, amikacin, and ertapenem, though even these, like all other comparators, were less consistently active against ESBL-positive isolates than against ESBL-negative isolates. Globally, 6.5% of isolates were ertapenem resistant based on the June 2010 clinical breakpoints published by the Clinical and Laboratory Standards Institute, with MICs of ≥1 μg/ml. Molecular characterization of 43 isolates with ertapenem MICs of ≥4 μg/ml showed that they variously produced CTX-M or SHV ESBLs combined with altered impermeability and/or had KPC (n = 28), OXA-48 (n = 3), or VIM (n = 1) carbapenemases. Further monitoring of ertapenem susceptibility and molecular characterization of ertapenem-resistant isolates are needed.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 24 Oct 2011 11:01 |
| Last Modified: | 23 Oct 2022 00:36 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/35140 |
| DOI: | 10.1128/AAC.00070-11 |
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