The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis

Wagstaff, Laura, Kelwick, Richard, Decock, Julie and Edwards, Dylan R. (2011) The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis. Frontiers in Bioscience, 16 (1). pp. 1861-1872.

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Abstract

The human ADAMTS (a disintegrin and metalloproteinase with thrombospondin-like motifs) family of 19 secreted, multidomain proteolytic enzymes is involved in a wide range of biological processes including ECM assembly and degradation, hemostasis, organogenesis and the regulation of angiogenesis. Defects in certain family members give rise to inherited human genetic diseases, while aberrant expression of other ADAMTSs has been linked to the pathogenesis of arthritis and cancer. Several ADAMTSs act as tumor or metastasis suppressors whose functions are lost either by mutation or epigenetic silencing during tumor progression. This review looks in depth at the involvement of ADAMTSs as positive and negative mediators in cancer growth and spread.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Users 2731 not found.
Date Deposited: 12 Oct 2011 11:34
Last Modified: 21 Apr 2020 16:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/35001
DOI: 10.2741/3827

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