AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters

Sicard, Delphine, Cecioni, Samy, Iazykov, Maksym, Chevolot, Yann, Matthews, Susan E. ORCID: https://orcid.org/0000-0001-8821-0851, Praly, Jean-Pierre, Souteyrand, Eliane, Imberty, Anne, Vidal, Sébastien and Phaner-Goutorbe, Magali (2011) AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters. Chemical Communications, 47 (33). pp. 9483-9485. ISSN 1359-7345

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Abstract

Atomic force microscopy reveals that Pseudomonas aeruginosa LecA (PA-IL) and a tetra-galactosylated 1,3-alternate calix[4]arene-based glycocluster self-assemble according to an aggregative chelate binding mode to create monodimensional filaments. Lectin oligomers are identified along the filaments and defects in chelate binding generate branches and bifurcations. A molecular model with alternate 90° orientation of LecA tetramers is proposed to describe the organisation of lectins and glycoclusters in the filaments.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Users 2731 not found.
Date Deposited:	12 Oct 2011 10:13
Last Modified:	23 Oct 2022 01:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/34990
DOI:	10.1039/C1CC13097H

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