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Vauzour, David 
ORCID: https://orcid.org/0000-0001-5952-8756, Ravaioli, Giulia, Vafeiadou, Katerina, Rodriguez-Mateos, Ana, Angeloni, Cristina and Spencer, Jeremy P. E.
(2008)
Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols.
Archives of Biochemistry and Biophysics, 476 (2).
pp. 145-151.
ISSN 0003-9861
Abstract
Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-catecholamine conjugates may contribute. In the present study, peroxynitrite was observed to generate both 2-S- and 5-S-cysteinyl-dopamine and a dihydrobenzothiazine species, DHBT-1, following the reaction of dopamine with l-cysteine. The formation of 5-S-cysteinyl-dopamine and DHBT-1 in the presence of peroxynitrite induced significant neuronal injury. Pre-treatment of cortical neurons with pelargonidin, quercetin, hesperetin, caffeic acid, the 4'-O-Me derivatives of catechin and epicatechin (0.1-3.0 microM) resulted in concentration dependant protection against 5-S-cysteinyl-dopamine-induced neurotoxicity. These data suggest that polyphenols may protect against neuronal injury induced by endogenous neurotoxins relevant to the aetiology of the Parkinson disease.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Depositing User: | David Vauzour |
| Date Deposited: | 29 Feb 2012 12:09 |
| Last Modified: | 19 Oct 2023 00:45 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/34822 |
| DOI: | 10.1016/j.abb.2008.03.011 |
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