Moderate Champagne consumption promotes an acute improvement in acute endothelIal-independent vascular function in healthy human volunteers

Vauzour, David, Houseman, Emily J., George, Trevor W., Corona, Giulia, Garnotel, Roselyne, Jackson, Kim G., Sellier, Christelle, Gillery, Philippe, Kennedy, Orla B., Lovegrove, Julie A. and Spencer, Jeremy P. E. (2010) Moderate Champagne consumption promotes an acute improvement in acute endothelIal-independent vascular function in healthy human volunteers. British Journal of Nutrition, 103 (8). pp. 1168-1178. ISSN 0007-1145

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Abstract

Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: David Vauzour
Date Deposited: 29 Feb 2012 11:36
Last Modified: 21 Apr 2020 17:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/34814
DOI:

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