Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens

Marches, Olivier, Wiles, Siouxsie, Dziva, Francis, La Ragione, Roberto M., Schuller, Stephanie, Best, Angus, Phillips, Alan D., Hartland, Elizabeth L., Woodward, Martin J., Stevens, Mark P. and Frankel, Gad (2005) Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens. Infection and Immunity, 73 (12). pp. 8411-8417. ISSN 0019-9567

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Abstract

Intestinal colonization by enteropathogenic and enterohemorrhagic Escherichia coli requires the locus of enterocyte effacement-encoded type III secretion system. We report that NleC and NleD are translocated into host cells via this system. Deletion mutants induced attaching and effacing lesions in vitro, while infection of calves or lambs showed that neither gene was required for colonization.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group
Depositing User:	Rhiannon Harvey
Date Deposited:	20 Jul 2011 09:31
Last Modified:	28 Mar 2025 04:08
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33954
DOI:	10.1128/IAI.73.12.8411-8417.2005

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