Shiga toxin binding in normal and inflamed human intestinal mucosa

Schuller, Stephanie, Heuschkel, Robert, Torrente, Franco, Kaper, James B. and Phillips, Alan D. (2007) Shiga toxin binding in normal and inflamed human intestinal mucosa. Microbes and Infection, 9 (1). pp. 35-39. ISSN 1286-4579

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Abstract

Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group
Depositing User:	Rhiannon Harvey
Date Deposited:	20 Jul 2011 09:25
Last Modified:	28 Mar 2025 03:44
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33949
DOI:	10.1016/j.micinf.2006.10.005

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