Delineation of the function of a major gamma delta T cell subset during infection.

Andrew, Elizabeth M, Newton, Darren J, Dalton, Jane E, Egan, Charlotte E, Goodwin, Stewart J, Tramonti, Daniela, Scott, Philip and Carding, Simon R (2005) Delineation of the function of a major gamma delta T cell subset during infection. Journal of Immunology, 175 (3). pp. 1741-1750. ISSN 0022-1767

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Gammadelta T cells play important but poorly defined roles in pathogen-induced immune responses and in preventing chronic inflammation and pathology. A major obstacle to defining their function is establishing the degree of functional redundancy and heterogeneity among gammadelta T cells. Using mice deficient in Vgamma1+ T cells which are a major component of the gammadelta T cell response to microbial infection, a specific immunoregulatory role for Vgamma1+ T cells in macrophage and gammadelta T cell homeostasis during infection has been established. By contrast, Vgamma1+ T cells play no significant role in pathogen containment or eradication and cannot protect mice from immune-mediated pathology. Pathogen-elicited Vgamma1+ T cells also display different functional characteristics at different stages of the host response to infection that involves unique and different populations of Vgamma1+ T cells. These findings, therefore, identify distinct and nonoverlapping roles for gammadelta T cell subsets in infection and establish the complexity and adaptability of a single population of gammadelta T cells in the host response to infection that is not predetermined, but is, instead, shaped by environmental factors.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 14 Jul 2011 10:44
Last Modified: 24 Oct 2022 02:10

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