Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing Enterobacteriaceae

Livermore, David M., Mushtaq, Shazad, Warner, Marina, Zhang, Jiancheng, Maharjan, Sunil, Doumith, Michel and Woodford, Neil (2011) Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing Enterobacteriaceae. Antimicrobial Agents and Chemotherapy, 55 (1). pp. 390-394. ISSN 0066-4804

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Abstract

Combinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of the Enterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum ß-lactamase (ESBL) or AmpC enzyme and also against most Klebsiella spp. with the KPC enzyme, but metallo-ß-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 µg/ml, including those with metallo-ß-lactamases.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 13 Jul 2011 11:12
Last Modified: 21 Apr 2020 16:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/33606
DOI: 10.1128/AAC.00756-10

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