Unlocking the genome of the human typhoid bacillus

Wain, John, House, Deborah, Parkhill, Julian, Parry, Christopher and Dougan, Gordon (2002) Unlocking the genome of the human typhoid bacillus. The Lancet Infectious Diseases, 2 (3). pp. 163-170. ISSN 1473-3099

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Molecular studies are shedding new light on the pathogenesis of human typhoid fever, which is still a very common disease in developing countries. For example, the total genome DNA sequence has recently been determined for a multiple-drug-resistant Salmonella typhi, the serotype that is the cause of typhoid fever. The genome sequence showed many distinguishing features, including clusters of S typhi specific genes and a large number--over 200--of pseudogenes. This information, together with other molecular studies, has provided vital clues in several important areas of typhoid biology. We have new insights into the mechanisms underpinning the human host specificity of S typhi, and have exploitable new routes to improved diagnostics and a better understanding of the epidemiology of the disease.

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Medical Microbiology (former - to 2018)
Depositing User: Rhiannon Harvey
Date Deposited: 13 Jul 2011 09:54
Last Modified: 24 Oct 2022 03:08
URI: https://ueaeprints.uea.ac.uk/id/eprint/33573
DOI: 10.1016/S1473-3099(02)00225-6

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