Cytokine Release by Lipopolysaccharide‐Stimulated Whole Blood from Patients with Typhoid Fever

House, Deborah, Chinh, Nguyen T., Hien, Tran T., Parry, Christopher P., Ly, Nguyen T., Diep, To S., Wain, John, Dunstan, Sarah, White, Nicholas J., Dougan, Gordon and Farrar, Jeremy J. (2002) Cytokine Release by Lipopolysaccharide‐Stimulated Whole Blood from Patients with Typhoid Fever. Journal of Infectious Diseases, 186 (2). pp. 240-245. ISSN 0022-1899

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Abstract

The ex vivo cytokine response to lipopolysaccharide (LPS) of whole blood from patients with typhoid fever was investigated. Tumor necrosis factor (TNF)–a release by LPS-stimulated blood was found to be lower during acute typhoid fever than after a course of antimicrobial therapy (P?.001). Ex vivo interleukin (IL)–1ß, but not IL-1 receptor antagonist, release was also depressed during the acute stage of typhoid fever. Low ex vivo production of TNF-a was associated with delayed recovery. No association was found between the TNFA-308 promoter polymorphism and LPS-induced TNF-a release, either during an active infection or after treatment. In acute typhoid fever, the ability of peripheral blood leukocytes to release proinflammatory cytokines in response to an inflammatory stimulus is depressed, and this may contribute to delayed recovery following antibiotic treatment

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 12 Jul 2011 11:24
Last Modified: 21 Apr 2020 20:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/33548
DOI: 10.1086/341298

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