Ertapenem resistance among Klebsiella and Enterobacter submitted in the UK to a reference laboratory

Woodford, Neil, Dallow, John W. T., Hill, Robert L. R., Palepou, Marie-France I., Pike, Rachel, Ward, M. Elaina, Warner, Marina and Livermore, David M. (2007) Ertapenem resistance among Klebsiella and Enterobacter submitted in the UK to a reference laboratory. International Journal of Antimicrobial Agents, 29 (4). pp. 456-459. ISSN 1872-7913

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Abstract

The emergence of carbapenem resistance in Enterobacteriaceae represents a major public health concern. We investigated ertapenem-resistant clinical isolates of Klebsiella spp. and Enterobacter spp. referred to the UK's national reference laboratory for antibiotic resistance. Minimum inhibitory concentrations (MICs) were determined and interpreted according to British Society for Antimicrobial Chemotherapy guidelines. Genes for carbapenemases and CTX-M extended-spectrum ß-lactamases (ESBLs) were sought by polymerase chain reaction, and imipenem hydrolysis was determined by spectrophotometry with crude extracts. From June 2004 to April 2006, 95 Klebsiella spp. and 76 Enterobacter spp. isolates resistant to ertapenem (MICs >2 mg/L) were received, 40% of which (38 Klebsiella spp. and 30 Enterobacter spp.) were highly resistant to ertapenem (MICs >16 mg/L). Imipenem and meropenem were active (geometric mean MICs

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 11 Jul 2011 10:38
Last Modified: 07 May 2020 23:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/33479
DOI: 10.1016/j.ijantimicag.2006.11.020

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