The β-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter

Livermore, David M ORCID: and Woodford, Neil (2006) The β-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter. Trends in Microbiology, 14 (9). pp. 413-420. ISSN 1878-4380

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Over the past 60 years, the use of successive generations of beta-lactam antibiotics has selected successive generations of beta-lactamase enzymes, each more potent than the last. Currently, rising problems include CTX-M extended-spectrum beta-lactamases (ESBLs), plasmid-mediated AmpC beta-lactamases and KPC carbapenemases in Enterobacteriaceae, while OXA- and metallo- carbapenemases are of growing importance in Acinetobacter spp. and (less so) in other non-fermenters. Escherichia coli isolates with CTX-M ESBLs are spreading multiresistance in the community and in hospitals, while carbapenemase-producing Acinetobacter spp., mostly from intensive care, are among the most multiresistant nosocomial bacteria known and are often susceptible only to polymyxins and, potentially, tigecycline. This review discusses the epidemiology and microbiology of these resistance problems, along with possible solutions.

Item Type: Article
Uncontrolled Keywords: acinetobacter,carbapenems,cephalosporins,drug resistance, multiple, bacterial,enterobacteriaceae,plasmids,pseudomonas,beta-lactam resistance,beta-lactamases
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 11 Jul 2011 10:27
Last Modified: 08 Feb 2023 17:30
DOI: 10.1016/j.tim.2006.07.008

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