Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients

Tomas, Maria, Doumith, Michel, Warner, Marina, Turton, Jane F., Beceiro, Alejandro, Bou, German, Livermore, David M. and Woodford, Neil (2010) Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrobial Agents and Chemotherapy, 54 (5). pp. 2219-2224. ISSN 0066-4804

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Abstract

Expression of ampC, oprD, mexA, mexC, mexE, and mexX was studied in 25 Pseudomonas aeruginosa isolates from cystic fibrosis patients, including 14 isolates of the Liverpool epidemic strain. Overexpressed mexA or ampC and reduced oprD were associated with beta-lactam resistance. A specific combination of mexR, nalC, and nalD mutations occurred in 11 Liverpool strain isolates, including 7 with upregulated mexA.

Item Type: Article
Uncontrolled Keywords: bacterial outer membrane proteins,bacterial proteins,cystic fibrosis,drug resistance, bacterial,drug resistance, multiple,electrophoresis, gel, pulsed-field,humans,membrane transport proteins,mutation,porins,pseudomonas infections,pseudomonas aeruginosa,reverse transcriptase polymerase chain reaction,up-regulation,beta-lactamases
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 05 Jul 2011 10:58
Last Modified: 21 Apr 2020 17:02
URI: https://ueaeprints.uea.ac.uk/id/eprint/33346
DOI: 10.1128/AAC.00816-09

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