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Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Item Type:	Article
Uncontrolled Keywords:	animals,disease models, animal,eating,environment,genetic variation,genome, human,genomics,humans,international cooperation,nutritional physiological phenomena,phenotype,research
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Social Sciences > School of Education and Lifelong Learning Faculty of Science > School of Biological Sciences
Related URLs:	http://dx.doi.org/10.1079/BJN20051585
Depositing User:	Rhiannon Harvey
Date Deposited:	04 Jul 2011 15:56
Last Modified:	21 Apr 2020 20:05
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33318
DOI:	10.1079/BJN20051585

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