The case for strategic international alliances to harness nutritional genomics for public and personal health

Kaput, Jim, Ordovas, Jose M, Ferguson, Lynnette, van Ommen, Ben, Rodriguez, Raymond L, Allen, Lindsay, Ames, Bruce N, Dawson, Kevin, German, Bruce, Krauss, Ronald, Malyj, Wasyl, Archer, Michael C, Barnes, Stephen, Bartholomew, Amelia, Birk, Ruth, van Bladeren, Peter, Bradford, Kent J, Brown, Kenneth H, Caetano, Rosane, Castle, David, Chadwick, Ruth, Clarke, Stephen, Clément, Karine, Cooney, Craig A, Corella, Dolores, Manica da Cruz, Ivana Beatrice, Daniel, Hannelore, Duster, Troy, Ebbesson, Sven O E, Elliott, Ruan, Fairweather-Tait, Susan, Felton, Jim, Fenech, Michael, Finley, John W, Fogg-Johnson, Nancy, Gill-Garrison, Rosalynn, Gibney, Michael J, Gillies, Peter J, Gustafsson, Jan-Ake, Hartman, John L, He, Lin, Hwang, Jae-Kwan, Jais, Jean-Philippe, Jang, Yangsoo, Joost, Hans, Junien, Claudine, Kanter, Mitchell, Kibbe, Warren A, Koletzko, Berthold, Korf, Bruce R, Kornman, Kenneth, Krempin, David W, Langin, Dominique, Lauren, Denis R, Ho Lee, Jong, Leveille, Gilbert A, Lin, Su-Ju, Mathers, John, Mayne, Michael, McNabb, Warren, Milner, John A, Morgan, Peter, Muller, Michael, Nikolsky, Yuri, van der Ouderaa, Frans, Park, Taesun, Pensel, Norma, Perez-Jimenez, Francisco, Poutanen, Kaisa, Roberts, Matthew, Saris, Wim H M, Schuster, Gertrud, Shelling, Andrew N, Simopoulos, Artemis P, Southon, Sue, Tai, E Shyong, Towne, Bradford, Trayhurn, Paul, Uauy, Ricardo, Visek, Willard J, Warden, Craig, Weiss, Rick, Wiencke, John, Winkler, Jack, Wolff, George L, Zhao-Wilson, Xi and Zucker, Jean-Daniel (2005) The case for strategic international alliances to harness nutritional genomics for public and personal health. British Journal of Nutrition, 94 (5). pp. 623-632. ISSN 0007-1145

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Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Item Type: Article
Uncontrolled Keywords: animals,disease models, animal,eating,environment,genetic variation,genome, human,genomics,humans,international cooperation,nutritional physiological phenomena,phenotype,research
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Social Sciences > School of Education and Lifelong Learning
Faculty of Science > School of Biological Sciences
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Depositing User: Rhiannon Harvey
Date Deposited: 04 Jul 2011 15:56
Last Modified: 14 Sep 2020 06:59
URI: https://ueaeprints.uea.ac.uk/id/eprint/33318
DOI: 10.1079/BJN20051585

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