Towards a total synthesis of the manadomanzamine alkaloids: the first asymmetric construction of the pentacyclic indole core

Allin, S. M., Duffy, L. J., Bulman Page, P. C. B., McKee, V. and McKenzie, M. J. (2007) Towards a total synthesis of the manadomanzamine alkaloids: the first asymmetric construction of the pentacyclic indole core. Tetrahedron Letters, 48 (27). pp. 4711-4714. ISSN 0040-4039

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Abstract

We report a highly diastereoselective approach for the synthesis of the pentacyclic indole core of the manadomanzamine alkaloid skeleton, with complete control over the relative and absolute stereochemistries at the three contiguous stereocentres at ring positions 1, 10, and 24, from a readily available chiral template. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: highly stereoselective-synthesis,natural-product synthesis,derivatives,enantiomers,pyrroloisoquinoline ring-system,facile,templates
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 20 Jun 2011 14:54
Last Modified: 21 Apr 2020 19:16
URI: https://ueaeprints.uea.ac.uk/id/eprint/32877
DOI: 10.1016/j.tetlet.2007.05.030

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