Bulman Page, P. C. B., Buckley, B. R., Heaney, H. and Blacker, A. J. (2005) Asymmetric epoxidation of cis-alkenes mediated by iminium salts: Highly enantioselective synthesis of levcromakalim. Organic Letters, 7 (3). pp. 375-377. ISSN 1523-7060
Full text not available from this repository. (Request a copy)Abstract
A range of cis-substituted olefins has been epoxidized with a new dihydroisoquinolinium salt catalyst, using tetraphenylphosphonium monoperoxysulfate as the stoichiometric oxidant, giving ee's of up to 97%. The reaction has been used as the key step in an enantioselertive synthesis of the antihypertensive agent levcromakalim.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Chemistry |
Depositing User: | Rachel Smith |
Date Deposited: | 20 Jun 2011 15:10 |
Last Modified: | 24 Oct 2022 02:15 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/32867 |
DOI: | 10.1021/ol047836h |
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