A short preparation of an advanced intermediate for lactacystin synthesis: The complete carbon skeleton of clasto-lactacystin dihydroxyacid

Bulman Page, Philip C., Leach, David C., Hayman, Colin M., Hamzah, A. Sazali, Allin, Steven M. and McKee, Vickie (2003) A short preparation of an advanced intermediate for lactacystin synthesis: The complete carbon skeleton of clasto-lactacystin dihydroxyacid. Synlett, 2003 (7). pp. 1025-1027. ISSN 0936-5214

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Abstract

An advanced intermediate 22 for lactacystin Synthesis, containing the full carbon skeleton of the pyrrolidinone component, has been achieved in four steps from a protected glycine ester.

Item Type:	Article
Uncontrolled Keywords:	proteasome inhibitors,dieckmann,lactacystin,route,analogs,clasto-lactacystin,tools,d-glucose,efficient,beta-lactone,acylation,(+)-lactacystin
Faculty \ School:	Faculty of Science > School of Chemistry
UEA Research Groups:	Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Depositing User:	Rachel Smith
Date Deposited:	21 Jun 2011 10:16
Last Modified:	11 Aug 2023 12:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32849
DOI:	10.1055/s-2003-39290

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