Novel synthesis of bis(phosphonic acid)-steroid conjugates

Bulman Page, Philip C., McKenzie, Michael J. and Gallagher, James A. (2001) Novel synthesis of bis(phosphonic acid)-steroid conjugates. Journal of Organic Chemistry, 66 (11). pp. 3704-3708. ISSN 0022-3263

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Abstract

An efficient synthesis has been realized for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic units linked at the 3 and 17 positions to a geminal bisphosphonate moiety through an ester linkage of variable length. The convergent synthesis utilizes benzyl bisphosphonates, transesterification, and Meldrum's acid chemistry and has the potential to allow many oestrogenic derivatives as well as other biologically active compounds to be coupled to the geminal bisphosphonate moeity.

Item Type: Article
Uncontrolled Keywords: bone,osteoporosis,alendronate,analogs,estrogen,ovariectomized rats,bisphosphonates,postmenopausal women,resorption,mechanisms
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 21 Jun 2011 11:19
Last Modified: 21 Apr 2020 20:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/32827
DOI: 10.1021/jo001489h

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