Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis

Winn, Michael, Goss, Rebecca J. M., Kimura, Ken-ichi and Bugg, Timothy D. H. (2010) Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure-function studies and nucleoside biosynthesis. Natural Product Reports, 27 (2). pp. 279-304. ISSN 0265-0568

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Abstract

The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.

Item Type: Article
Additional Information: Winn, Michael Goss, Rebecca J. M. Kimura, Ken-ichi Bugg, Timothy D. H.
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 16 Jun 2011 09:02
Last Modified: 21 Apr 2020 17:24
URI: https://ueaeprints.uea.ac.uk/id/eprint/32663
DOI: 10.1039/b816215h

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