Expression of immediate early genes in sensory ganglia

Groneberg, David A., Wiegand, Silke, Dinh, Q. Thai, Peiser, Christian, Springer, Jochen and Fischer, Axel (2001) Expression of immediate early genes in sensory ganglia. Neurochemical Research, 26 (10). pp. 1113-1117. ISSN 1573-6903

Full text not available from this repository.


C-Jun and c-Fos belong to the family of immediate early genes. Apart from their role as transcription factors, a basal expression was shown for them in central nervous system tissues. The expression of c-Jun and c-Fos in sensory ganglia of guinea pig, rat and murine sensory ganglia was examined under normal, unstimulated conditions by quantitative double-immunohistochemistry. 4.6 ± 2.8% of neuron-specific protein gene-product 9.5 -positive cells in nodose ganglia, 51.6 ± 2.1% in jugular ganglia, 46.4 ± 3.0% in trigeminal ganglia and 42.5 ± 1.3% of cervical dorsal root ganglia neurons were positive for c-Jun in the guinea pig (less than 1% for c-Fos). In rat and mouse, less than 1% of the sensory neurons exhibited c-Jun and c-Fos-immunoreactivity. The high basal expression of c-Jun in guinea pig sensory neurons suggests that in this species the presence of c-Jun does not only depend on specific stimulation and is not exclusively associated with neuronal plasticity of gene expression and functional changes.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Related URLs:
Depositing User: Rhiannon Harvey
Date Deposited: 09 Jun 2011 15:09
Last Modified: 15 Dec 2022 01:49
DOI: 10.1023/A:1012366721845

Actions (login required)

View Item View Item