Expression of immediate early genes in sensory ganglia

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Groneberg, David A., Wiegand, Silke, Dinh, Q. Thai, Peiser, Christian, Springer, Jochen and Fischer, Axel (2001) Expression of immediate early genes in sensory ganglia. Neurochemical Research, 26 (10). pp. 1113-1117. ISSN 1573-6903

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Abstract

C-Jun and c-Fos belong to the family of immediate early genes. Apart from their role as transcription factors, a basal expression was shown for them in central nervous system tissues. The expression of c-Jun and c-Fos in sensory ganglia of guinea pig, rat and murine sensory ganglia was examined under normal, unstimulated conditions by quantitative double-immunohistochemistry. 4.6 ± 2.8% of neuron-specific protein gene-product 9.5 -positive cells in nodose ganglia, 51.6 ± 2.1% in jugular ganglia, 46.4 ± 3.0% in trigeminal ganglia and 42.5 ± 1.3% of cervical dorsal root ganglia neurons were positive for c-Jun in the guinea pig (less than 1% for c-Fos). In rat and mouse, less than 1% of the sensory neurons exhibited c-Jun and c-Fos-immunoreactivity. The high basal expression of c-Jun in guinea pig sensory neurons suggests that in this species the presence of c-Jun does not only depend on specific stimulation and is not exclusively associated with neuronal plasticity of gene expression and functional changes.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	https://link.springer.com/article/10.102...
Depositing User:	Rhiannon Harvey
Date Deposited:	09 Jun 2011 15:09
Last Modified:	15 Dec 2022 01:49
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32171
DOI:	10.1023/A:1012366721845

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