Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus

Peiser, Christian, Springer, Jochen, Groneberg, David A., McGregor, Gerard P., Fischer, Axel and Lang, Rudolf E. (2002) Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus. Neuroscience Letters, 320 (1-2). pp. 41-44. ISSN 1872-7972

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Recent studies suggest that in addition to adipocytes the chief cells of the gastric fundic mucosa are a site of leptin production. In order to assess the possible role of vagal afferent neurons in transmitting leptin signals from the stomach to the brain, leptin receptor (OB-R) expression was investigated in rat nodose ganglion cells and their projection to the stomach determined by retrograde tracing. Reverse transcription-polymerase chain reaction combined with laser-assisted cell picking revealed that large and small diameter neurons express both the long (OB-Rb) and short (OB-Ra) splice variants of the OB-R. OB-R like immunoreactivity was detected in the perikarya of approximately 8% of nodose ganglion neurons. Tracing studies revealed that a significant proportion (15%) of the immunopositive neurons projected to the gastric fundus. These findings suggest that leptin may use a neural route to relay its message from peripheral sites of leptin synthesis such as the gastric fundus to the brain.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Rhiannon Harvey
Date Deposited: 09 Jun 2011 15:06
Last Modified: 15 Dec 2022 01:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/32169
DOI: 10.1016/S0304-3940(02)00023-X

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