Human osteoclast culture from peripheral blood monocytes: Phenotypic characterization and quantitation of resorption

Buckley, Katherine A., Chan, Benjamin Y. Y., Fraser, William D. and Gallagher, James A. (2004) Human osteoclast culture from peripheral blood monocytes: Phenotypic characterization and quantitation of resorption. Methods in Molecular Medicine, 107. 055-068.

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Abstract

Research involving osteoclasts has always been difficult to undertake owing to a lack of osteoclast supply. Osteoclasts are terminally differentiated cells and, therefore, they cannot simply divide and be maintained in culturean osteoclast supply must constantly be replenished. Osteoclasts are large, multinucleated cells formed by the fusion of osteoclast precursors found in the monocyte fraction of blood. The osteoclast is thought to be the only cell capable of excavating authentic resorption lacunae in calcified substrates in vivo and in vitro.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Rhiannon Harvey
Date Deposited:	08 Jun 2011 12:35
Last Modified:	25 Apr 2025 00:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32052
DOI:	10.1385/1-59259-861-7:055

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