Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients

White, H. D., Ahmad, A. M., Durham, B. H., Patwala, A., Whittingham, P., Fraser, W. D. and Vora, J. P. (2005) Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients. Journal of Clinical Endocrinology & Metabolism, 90 (6). pp. 3371-3380. ISSN 0021-972X

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Abstract

Alterations in PTH circadian rhythm and PTH target-organ sensitivity exist in adult GH-deficient (AGHD) patients and may underlie the pathogenesis of AGHD-related osteoporosis. GH replacement (GHR) results in increased bone mineral density, but its benefit in AGHD patients over 60 yr old has been debated.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Rhiannon Harvey
Date Deposited:	08 Jun 2011 12:29
Last Modified:	25 Apr 2025 00:02
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32049
DOI:	10.1210/jc.2004-1650

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