Susceptibility to Paget's disease of bone is influenced by a common polymorphic variant of osteoprotegerin

Daroszewska, Anna, Hocking, Lynne J, McGuigan, Fiona E A, Langdahl, Bente, Stone, Michael D, Cundy, Tim, Nicholson, Geoff C, Fraser, William D and Ralston, Stuart H (2004) Susceptibility to Paget's disease of bone is influenced by a common polymorphic variant of osteoprotegerin. Journal of Bone and Mineral Research, 19 (9). pp. 1506-1511. ISSN 1523-4681

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Abstract

To clarify the role of the TNFRSF11B gene encoding osteoprotegerin (OPG), in Paget's disease of bone (PDB) we studied TNFRSF11B polymorphisms in an association study of 690 UK subjects and in a worldwide familial study of 66 kindreds. We found that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to both sporadic and familial PDB.

Item Type:	Article
Uncontrolled Keywords:	aged,aged, 80 and over,case-control studies,dna mutational analysis,female,genetic predisposition to disease,humans,male,osteitis deformans,osteoprotegerin,polymorphism, single nucleotide,receptors, tumor necrosis factor
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Rhiannon Harvey
Date Deposited:	08 Jun 2011 11:48
Last Modified:	19 Oct 2023 00:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32036
DOI:	10.1359/JBMR.040602

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