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McDermott, Michael C., Stephenson, G. Richard 
ORCID: https://orcid.org/0000-0003-1487-9178, Hughes, David L. and Walkington, Andrew J.
(2006)
Intramolecular asymmetric Heck reactions: Evidence for dynamic kinetic resolution effects.
Organic Letters, 8 (14).
pp. 2917-2920.
ISSN 1523-7060
Abstract
Enantioselectivity of the cyclization of 1 varies at different stages in the reaction. X-ray crystallography has shown that 1 exists as enantiomerically pure (M) and (P) chiral helical structures defined by the relative orientations of the arene, amide, and alkene. The relative rates of interconversion of the rotamers of 1 have been established, leading to mechanistic proposals to account for the variation of ee based on kinetic resolution effects.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Chemistry |
| Depositing User: | Rachel Smith |
| Date Deposited: | 08 Jun 2011 10:47 |
| Last Modified: | 24 Oct 2022 01:56 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/32009 |
| DOI: | 10.1021/ol0606132 |
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