Flavonoid derivatives as organometallic bioprobes

Anson, Christopher E., Creaser, Colin S., Malkov, Andrej V., Mojovic, Ljubica and Stephenson, G. Richard (2003) Flavonoid derivatives as organometallic bioprobes. Journal of Organometallic Chemistry, 668 (1-2). pp. 101-122. ISSN 0022-328X

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Abstract

The synthesis of organoiron derivatives of biologically active flavonoids is described. Lithium enolates of functionalised protected acetophenones and metallated derivatives of substituted aromatic rings have been employed as nucleophiles in combination with tricarbonyl(eta(5)-cyclohexadienyl)iron electrophiles. Products have been converted into flavonoid and chalcone derivatives. Enolates generated from protected flavanones have also been used in nucleophile addition reactions, and a one-pot in situ protection, nucleophile addition, deprotection sequence is reported. (C) 2003 Elsevier Science B.V. All rights reserved.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 08 Jun 2011 11:02
Last Modified: 21 Apr 2020 20:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/32003
DOI: 10.1016/s0022-328x(02)02146-0

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