Cellular strategies for proteolytic targeting during migration and invasion

Ellis, Vincent and Murphy, Gillian (2001) Cellular strategies for proteolytic targeting during migration and invasion. FEBS Letters, 506. pp. 1-5. ISSN 1873-3468

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Abstract

Cell migration over or through the extracellular matrix (ECM) is an integral feature of both physiological and pathological processes. Regulation of the changing cell–ECM interactions involved can be effected by proteolysis and requires strict spatial and temporal targeting of proteinase activity. The versatile use of different proteinase systems, with a variety of localisation mechanisms and cleavage targets, is being revealed by a plethora of studies using in vitro models. This mini review reflects the status of our knowledge of strategies for the localisation of proteolytic activity effected during cell migration.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: EPrints Services
Date Deposited: 01 Oct 2010 13:36
Last Modified: 15 Dec 2022 01:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/319
DOI: 10.1016/S0014-5793(01)02845-9

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