Antioxidant and anti-atherogenic activities of olive oil phenolics

Turner, Rufus, Etienne, Nicolas, Alonso, Maria Garcia, de Pascual-Teresa, Sonia, Minihane, Anne Marie, Weinberg, Peter D. and Rimbach, Gerald (2005) Antioxidant and anti-atherogenic activities of olive oil phenolics. International Journal for Vitamin and Nutrition Research, 75 (1). pp. 61-70. ISSN 0300-9831

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Abstract

The aim of the current study was to investigate the antioxidant and cellular activity of the olive oil phenolics oleuropein, tyrosol, hydroxytyrosol, and homovanillic alcohol (which is also a major metabolite of hydroxytyrosol). Well-characterized chemical and biochemical assays were used to assess the antioxidant potential of the compounds. Further experiments investigated their influence in cell culture on cytotoxic effects of hydrogen peroxide and oxidized low-density lipoprotein (LDL), nitric oxide production by activated macrophages, and secretion of chemoattractant and cell adhesion molecules by the endothelium. Inhibitory influences on in vitro platelet aggregation were also measured. The antioxidant assays indicated that homovanillic alcohol was a significantly more potent antioxidant than the other phenolics, both in chemical assays and in prolonging the lag phase of LDL oxidation. Cell culture experiments suggested that the olive oil phenolics induce a significant reduction in the secretion of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 (and a trend towards a reduced secretion of monocyte chemoattractant protein-1), and protect against cytotoxic effects of hydrogen peroxide and oxidized LDL. However, no influence on nitric oxide production or platelet aggregation was evident. The data show that olive oil phenolics have biochemical and cellular actions, which, if also apparent in vivo, could exert cardioprotective effects.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 01 Jun 2011 08:20
Last Modified: 27 Apr 2020 23:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/31647
DOI: 10.1024/0300-9831.75.1.61

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