Polymorphisms in the Apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males

Page, Nigel M., Olano-Martin, Estibaliz, Lanaway, Christopher, Turner, Rufus and Minihane, Anne Marie ORCID: https://orcid.org/0000-0001-9042-4226 (2006) Polymorphisms in the Apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males. Genes & Nutrition, 1 (2). pp. 133-135. ISSN 1555-8932

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Abstract

Apolipoprotein L1 in plasma is associated with high-density lipoprotein. Novel APOL1 polymorphisms are investigated along with the association of two common haplotypes (Lysl66Glu, Ile244Met, Lys271Arg) with circulating lipid and glucose levels. Although the amino acid substitutions occur in the amphipathic alpha helices region involved in lipid binding, these substitutions were found not to independently account for variability in circulating lipid and glucose levels in 149 middle age males.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Rhiannon Harvey
Date Deposited:	31 May 2011 14:55
Last Modified:	19 Oct 2023 00:50
URI:	https://ueaeprints.uea.ac.uk/id/eprint/31616
DOI:	10.1007/BF02829955

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