Fatty acid–genotype interactions and cardiovascular risk

Minihane, Anne M ORCID: https://orcid.org/0000-0001-9042-4226 (2010) Fatty acid–genotype interactions and cardiovascular risk. Prostaglandins, Leukotrienes and Essential Fatty Acids, 82 (4-6). pp. 259-264.

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Cardiovascular disease (CVD) risk and rate of progression is determined by genetic, environmental and behavioural factors. Majority of genotype–diet–CVD phenotype research till date has focussed on the interactive impact of single nucleotide polymorphisms (SNP) and dietary fat composition, on blood lipids levels, with strong evidence of the existence of hypo- and hyper-responders. However, a recognised concern in the field of nutrigenetics is a lack of consistency between findings of different studies. This apparent lack of consistency is likely to be attributable to the impact of factors such as ethnicity and gender on the ‘size’ of nutrigenetic interactions, a clear understanding of which needs to be gained. Although not yet ready for widespread use, in the future a greater use of genetic profiling is likely to enhance current strategies of CVD prediction, and improve the design of more personalised approaches to minimise risk in the individual.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 31 May 2011 13:56
Last Modified: 22 Dec 2022 13:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/31585
DOI: 10.1016/j.plefa.2010.02.014

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