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Matthews, Susan E. 
ORCID: https://orcid.org/0000-0001-8821-0851, Pouton, Colin W. and Threadgill, Michael D.
(2001)
Formation of hybrid polymethylene-poly(oxyethylene) macrocycles.
Tetrahedron Letters, 42 (7).
pp. 1355-1357.
ISSN 0040-4039
Abstract
Maclocyclisations, particularly those forming crown ethers, normally require high dilution conditions. However, treatment of 1,9-bis(sarcosylamino)nonane with alpha,omega -bis(oxiranylmethyl) ethers derived from oligomeric poly(ethyleneglycol)s of MW 400-600 Da under high concentration conditions was found to give excellent yields of 1:1 hybrid polymethylene-poly(oxyethylene) macrocyclic crown ether derivatives. The corresponding alpha,omega -bis(oxiranylmethyl) ether derived from poly(ethyleneglycol) of mean MW 1500 Da gave polymeric material only. The macrocycles were characterised by NMR, GPC and MS. (C) 2001 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | crown-ethers |
| Faculty \ School: | Faculty of Science > School of Pharmacy |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) |
| Depositing User: | Rachel Smith |
| Date Deposited: | 31 May 2011 10:26 |
| Last Modified: | 15 Aug 2023 13:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/31511 |
| DOI: | 10.1016/S0040-4039(00)02231-0 |
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