Thermal studies of solvent exchange in isostructural solvates of a tetroxoprim-sulfametrole complex

Bettinetti, G. P., Caira, M. R., Sorrenti, M., Catenacci, L., Ghirardi, M. and Fabian, L. (2004) Thermal studies of solvent exchange in isostructural solvates of a tetroxoprim-sulfametrole complex. Journal of Thermal Analysis and Calorimetry, 77 (2). pp. 695-708. ISSN 1388-6150

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Abstract

Isostructural solvates of the 1: 1 molecular complex between the antibacterial drugs tetroxoprim (TXP) and sulfametrole (SMTR) with formulae TXP . SMTR . CH3OH ( I), TXP . SMTR.C2H5OH (II) and TXP . SMTR . H2O ( III), were investigated to establish their propensity for guest exchange. Separate exposure of powdered ( I), ( II) and ( III) to a saturated atmosphere of each solvent of the complementary solvate pair at ambient temperature resulted in reversible solvent exchange in all cases. DSC and TG were the methods of choice for monitoring the exchange processes since ( I) -( III) have distinct onset temperatures of desolvation and characteristic mass losses. Interpretation of the results in terms of the known locations of the solvent molecules in crystals of ( I) -( III) led to the conclusion that solvent exchange probably proceeds by a co-operative mechanism involving material transport through channels while the common host framework is maintained.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Rachel Smith
Date Deposited:	19 May 2011 10:17
Last Modified:	24 Oct 2022 02:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30983
DOI:	10.1023/B:JTAN.0000039004.35684.e6

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