Practical synthesis of sugar monophosphonucleotides

Wlassoff, W. A., Finlay, R. M. J. and Hamilton, C. J. (2007) Practical synthesis of sugar monophosphonucleotides. Synthetic Communications, 37 (17). pp. 2927-2934. ISSN 0039-7911

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A reliable procedure for the preparation of sugar nucleoside monophosphates is presented, which involves condensation of an activated glycosyl-1-H-phosphonate with an appropriately protected nucleoside and simple end-product isolation via lithium perchlorate-induced precipitation. The utility of these methods is demonstrated by the preparation of a number of purine- and pyrimidine-based sugar nucleoside monophosphate derivatives.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017)
Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User: Rachel Smith
Date Deposited: 17 May 2011 15:51
Last Modified: 24 Oct 2022 01:35
DOI: 10.1080/00397910701471543

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