Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

Van Haaften, Gijs, Dalgliesh, Gillian L, Davies, Helen, Chen, Lina, Bignell, Graham, Greenman, Christopher, Edkins, Sarah, Hardy, Claire, O'meara, Sarah, Teague, Jon, Butler, Adam, Hinton, Jonathan, Latimer, Calli, Andrews, Jenny, Barthorpe, Syd, Beare, Dave, Buck, Gemma, Campbell, Peter J, Cole, Jennifer, Forbes, Simon, Jia, Mingming, Jones, David, Kok, Chai Yin, Leroy, Catherine, Lin, Meng-lay, Mcbride, David J, Maddison, Mark, Maquire, Simon, Mclay, Kirsten, Menzies, Andrew, Mironenko, Tatiana, Mulderrig, Lee, Mudie, Laura, Pleasance, Erin, Shepherd, Rebecca, Smith, Raffaella, Stebbings, Lucy, Stephens, Philip, Tang, Gurpreet, Tarpey, Patrick S, Turner, Rachel, Turrell, Kelly, Varian, Jennifer, West, Sofie, Widaa, Sara, Wray, Paul, Collins, V Peter, Ichimura, Koichi, Law, Simon, Wong, John, Yuen, Siu Tsan, Leung, Suet Yi, Tonon, Giovanni, Depinho, Ronald A, Tai, Yu-tzu, Anderson, Kenneth C, Kahnoski, Richard J, Massie, Aaron, Khoo, Sok Kean, Teh, Bin Tean, Stratton, Michael R and Futreal, P Andrew (2009) Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genetics, 41 (5). pp. 521-523. ISSN 1061-4036

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Abstract

Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.

Item Type: Article
Faculty \ School: Faculty of Science > School of Computing Sciences

University of East Anglia > Faculty of Science > Research Groups > Computational Biology (subgroups are shown below) > Analysis and models of genomic variation
Depositing User: Christopher Greenman
Date Deposited: 22 Jun 2011 11:23
Last Modified: 21 Apr 2020 17:49
URI: https://ueaeprints.uea.ac.uk/id/eprint/30594
DOI: 10.1038/ng.349

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