The Role of Annexin A5 in the Modulation of the Immune Response Against Dying and Dead Cells

Munoz, LE, Frey, B, Pausch, F, Baum, W, Mueller, RB, Brachvogel, B, Poschl, E, Rodel, F, von der Mark, K, Herrmann, M and Gaipl, US (2007) The Role of Annexin A5 in the Modulation of the Immune Response Against Dying and Dead Cells. Working Paper. UNSPECIFIED.

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Abstract

Annexins are characterized by the ability to bind phospholipids of membranes in the presence of Ca2+. Annexin A5 represents a typical member of this protein family and is a natural occurring highly specific ligand for phosphatidylserine (PS). The exposure of PS is one major “eat me” signal for phagocytes of apoptotic and necrotic cells. Apoptotic cells are normally cleared via an anti-inflammatory pathway. In contrast, the uptake and removal of necrotic cells normally involves inflammation and an immune response. Interestingly, the lack of endogenous annexin A5 also leads to a reduced inflammatory potential of necrotic cells. Annexin A5 may interfere in vivo with the immunosuppressive effects of apoptotic cells since it preferentially binds PS with high affinity and inhibits apoptotic cell uptake by macrophages. In this review we focus on how defects in the clearance process can lead to chronic autoimmunity. Furthermore, the role of annexin A5 as important adjuvant for apoptotic cell-based tumour vaccines is discussed. The mechanism of how the immunogenicity of apoptotic cells can be restored by blocking their PS-dependent clearance is outlined in detail. Taken together, annexin A5 is an important modulator of the immune response against PSexposing particles like apoptotic cells, necrotic cells, and certain viruses.

Item Type: Monograph (Working Paper)
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: Users 2731 not found.
Date Deposited: 16 May 2011 12:42
Last Modified: 02 Jun 2020 23:34
URI: https://ueaeprints.uea.ac.uk/id/eprint/30591
DOI: 10.2174/092986707779941131

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