The cholesterol paradox revisited: Heart failure, systemic inflammation, and beyond

von Haehling, Stephan, Schefold, Joerg C., Springer, Jochen and Anker, Stefan D. (2008) The cholesterol paradox revisited: Heart failure, systemic inflammation, and beyond. Heart Failure Clinics, 4 (2). pp. 141-151.

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Abstract

The pathophysiologic understanding of chronic heart failure has made significant advances over the last decades. Counterintuitively, high levels of plasma cholesterol are associated with better survival, perhaps because plasma lipoproteins are able to scavenge lipopolysaccharide, a cell-wall component from gram-negative bacteria. A number of similar features are present in patients who have sepsis. This article explores the cholesterol paradox in patients who have chronic heart failure and extends this view to patients who have sepsis. Also discussed is the potential of statins, which might be able to exert beneficial effects in both clinical conditions, despite lowering plasma cholesterol values.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Rhiannon Harvey
Date Deposited:	05 May 2011 15:57
Last Modified:	25 Jan 2023 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/29953
DOI:	10.1016/j.hfc.2008.01.009

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