Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure.

Sandek, Anja, Bjarnason, Ingvar, Volk, Hans-Dieter, Crane, Roger, Meddings, Jonathan B, Niebauer, Josef, Kalra, Paul R, Buhner, Sabine, Herrmann, Ralph, Springer, Jochen, Doehner, Wolfram, von Haehling, Stephan, Anker, Stefan D and Rauchhaus, Mathias (2012) Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure. International Journal of Cardiology, 157 (1). 80–85. ISSN 1874-1754

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Abstract

BACKGROUND: Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF. METHODS: We measured intestinal permeability (melibiose and rhamnose), active (3-O-methyl-d-glucose (3-OMG)) and passive (d-xylose) carrier-mediated absorption in 20 CHF patients (12 edematous and 8 non-edematous) and 8 controls by saccharide absorption technique assessing urinary recovery of orally administered sugars. We additionally measured LPS concentrations in 42 patients with decompensated heart failure and after recompensation. RESULTS: CHF patients had a 54% reduction of active carrier-mediated intestinal transport compared to controls (p

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Rhiannon Harvey
Date Deposited:	05 May 2011 15:53
Last Modified:	23 Oct 2022 01:08
URI:	https://ueaeprints.uea.ac.uk/id/eprint/29952
DOI:	10.1016/j.ijcard.2010.12.016

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