Autoimmune disease as a risk factor for globus pharyngeus: a cross-sectional epidemiological study

Masterson, L. M., Srouji, I. A., Musonda, P. and Scott, D. G. I. (2011) Autoimmune disease as a risk factor for globus pharyngeus: a cross-sectional epidemiological study. Clinical Otolaryngology, 36 (1). pp. 24-29. ISSN 1749-4486

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Objective: To assess the prevalence and severity of globus-type symptoms in individuals who have a prior diagnosis of autoimmune disease. Design: Cross-sectional questionnaire. Participants and setting: One hundred and nine patients with autoimmune disease (rheumatoid arthritis, seronegative spondarthritis, connective tissue disease, systemic vasculitis) and 41 patients with non-autoimmune disease (osteoarthritis/osteoporosis) attending a rheumatology tertiary referral clinic at Norfolk & Norwich University Hospitals NHS Foundation Trust. The results from this study were compared to previous published figures in patients with globus pharyngeus (n = 105) and normal population (n = 174). Main outcome measures: Glasgow Edinburgh Throat Scale questionnaire; Reflux Symptom Index; Anxiety/Depression Scale. Results: Patients with autoimmune disease demonstrate a significantly higher prevalence for 5/10 symptoms on the Glasgow Edinburgh Throat scale score when compared to the non-autoimmune control group (P ≤ 0.01). This significant difference increases to 9/10 symptoms when compared to published results for the normal population (P = 0.01). No significant difference was found when comparing the autoimmune and non-autoimmune control group reflux symptom index (P = 0.64) or anxiety depression scale (P = 0.71). Conclusion: Patients with autoimmune disease have a significantly increased prevalence of globus symptoms when compared to the healthy population. A further prospective study is required to decipher the effect of pharmacotherapy as a possible causative factor.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 28 Apr 2011 08:24
Last Modified: 21 Nov 2022 11:30
DOI: 10.1111/j.1749-4486.2010.02243.x

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