Diabetes insipidus as a complication of Wegener's granulomatosis and its treatment with biologic agents

Cunnington, Joanna Rosalind, Jois, Ramesh, Zammit, Ivan, Scott, David and Isaacs, John (2009) Diabetes insipidus as a complication of Wegener's granulomatosis and its treatment with biologic agents. International Journal of Rheumatology, 2009. ISSN 1687-9260

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Abstract

Wegener's granulomatosis of the pituitary gland resulting in diabetes insipidus is a rare complication of the disease. Standard treatment for Wegener's granulomatosis involves a combination of prednisolone and cylophosphamide, however biologic agents are now being used in refractory cases. We report three cases of patients with diabetes insipidus as a complication of Wegener's granulomatosis who were treated with biologic agents. All three cases showed clinical response to treatment with biologic agents including rituximab and alemtuzumab and two cases demonstrated improvement in pituitary gland abnormalities by MRI. Clinicians should be aware that diabetes insipidus can present as a complication of Wegener's granulomatosis and that biologic therapies may be effective in refractory cases.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Rhiannon Harvey
Date Deposited:	27 Apr 2011 15:37
Last Modified:	05 Jan 2023 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/29822
DOI:	10.1155/2009/346136

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