Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization

Belluoccio, D, Grskovic, I, Niehoff, A, Schlotzer-Schrehardt, U, Rosenbaum, S, Etich, J, Frie, C, Pausch, F, Moss, SE, Poschl, E, Bateman, JF and Brachvogel, B (2009) Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization. Journal of Bone and Mineral Research, 25 (1). pp. 141-153. ISSN 1523-4681

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Abstract

Initiation of mineralization during endochondral ossification is a multistep process and has been assumed to correlate with specific interactions of annexins A5 and A6 and collagens. However, skeletal development appears to be normal in mice deficient for either A5 or A6, and the highly conserved structures led to the assumption that A5 and A6 may fulfill redundant functions. We have now generated mice deficient of both proteins. These mice were viable and fertile and showed no obvious abnormalities. Assessment of skeletal elements using histologic, ultrastructural, and peripheral quantitative computed tomographic methods revealed that mineralization and development of the skeleton were not significantly affected in mutant mice. Otherwise, global gene expression analysis showed subtle changes at the transcriptome level of genes involved in cell growth and intermediate metabolism. These results indicate that annexins A5 and A6 may not represent the essential annexins that promote mineralization in vivo.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: EPrints Services
Date Deposited: 01 Oct 2010 13:36
Last Modified: 23 Apr 2020 23:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/291
DOI: 10.1359/jbmr.090710

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